Browse by author
Lookup NU author(s): Professor David SteelORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The AuthorsSubretinal injection is the preferred delivery technique for various novel ocular therapies and is widely used because of its precision and efficient delivery of gene and cell therapies; however, choosing an injection point and defining delivery parameters to target a specified retinal location and area is an inexact science. We provide an overview of the key factors that play important roles during subretinal injections to refine the technique, enhance patient outcomes, and minimise risks. We describe the role of anatomical and physical variables that affect subretinal bleb propagation and shape and their impact on retinal integrity. We highlight the risks associated with subretinal injections and consider strategies to mitigate reflux and retinal trauma. Finally, we explore the emerging field of robotic assistance in improving intraocular manouvrability and precision to facilitate the injection procedure.
Author(s): L'Abbate D, Prescott K, Geraghty B, Kearns VR, Steel DHW
Publication type: Review
Publication status: Published
Journal: Survey of Ophthalmology
Year: 2024
Volume: 69
Issue: 5
Pages: 722-732
Print publication date: 01/09/2024
Online publication date: 24/05/2024
Acceptance date: 20/05/2024
ISSN (print): 0039-6257
ISSN (electronic): 1879-3304
Publisher: Elsevier Inc.
URL: https://doi.org/10.1016/j.survophthal.2024.05.004
DOI: 10.1016/j.survophthal.2024.05.004
PubMed id: 38797394
