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Molecular Pathways and Animal Models of Truncus Arteriosus

Lookup NU author(s): Dr Ellie Gill, Dr Simon BamforthORCiD

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Abstract

© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG. In normal cardiovascular development in birds and mammals, the outflow tract of the heart is divided into two distinct channels to separate the oxygenated systemic blood flow from the deoxygenated pulmonary circulation. When the process of outflow tract septation fails, a single common outflow vessel persists resulting in a serious clinical condition known as persistent truncus arteriosus or common arterial trunk. In this chapter, we will review molecular pathways and the cells that are known to play a role in the formation and development of the outflow tract and how genetic manipulation of these pathways in animal models can result in common arterial trunk.


Publication metadata

Author(s): Gill E, Bamforth SD

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart. Clinical Features, Human Genetics and Molecular Pathways

Year: 2024

Volume: 1441

Pages: 853-865

Online publication date: 18/06/2024

Acceptance date: 02/04/2018

Publisher: Springer

Place Published: Cham

URL: https://doi.org/10.1007/978-3-031-44087-8_52

DOI: 10.1007/978-3-031-44087-8_52

PubMed id: 38884754

Library holdings: Search Newcastle University Library for this item

ISBN: 9783031440861


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