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Lookup NU author(s): Dr Ellie Gill, Dr Simon BamforthORCiD
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© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG. In normal cardiovascular development in birds and mammals, the outflow tract of the heart is divided into two distinct channels to separate the oxygenated systemic blood flow from the deoxygenated pulmonary circulation. When the process of outflow tract septation fails, a single common outflow vessel persists resulting in a serious clinical condition known as persistent truncus arteriosus or common arterial trunk. In this chapter, we will review molecular pathways and the cells that are known to play a role in the formation and development of the outflow tract and how genetic manipulation of these pathways in animal models can result in common arterial trunk.
Author(s): Gill E, Bamforth SD
Publication type: Book Chapter
Publication status: Published
Book Title: Congenital Heart Diseases: The Broken Heart. Clinical Features, Human Genetics and Molecular Pathways
Year: 2024
Volume: 1441
Pages: 853-865
Online publication date: 18/06/2024
Acceptance date: 02/04/2018
Publisher: Springer
Place Published: Cham
URL: https://doi.org/10.1007/978-3-031-44087-8_52
DOI: 10.1007/978-3-031-44087-8_52
PubMed id: 38884754
Library holdings: Search Newcastle University Library for this item
ISBN: 9783031440861