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Molecular Pathways and Animal Models of d-Transposition of the Great Arteries

Lookup NU author(s): Dr Ellie Gill, Dr Simon BamforthORCiD

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Abstract

© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG. During normal cardiovascular development, the outflow tract becomes septated and rotates so that the separate aorta and pulmonary trunk are correctly aligned with the left and right ventricles, respectively. However, when this process goes wrong, the aorta and pulmonary trunk are incorrectly positioned, resulting in oxygenated blood being directly returned to the lungs, with deoxygenated blood being delivered to the systemic circulation. This is termed transposition of the great arteries (TGA). The precise etiology of TGA is not known, but the use of animal models has elucidated that genes involved in determination of the left- embryonic body axis play key roles. Other factors such as retinoic acid levels are also crucial. This chapter reviews the animal models presenting with TGA that have been generated by genetic manipulation or with exogenous agents.


Publication metadata

Author(s): Gill E, Bamforth SD

Editor(s): Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart. Clinical Features, Human Genetics and Molecular Pathways

Year: 2024

Volume: 1441

Pages: 683-696

Online publication date: 18/06/2024

Acceptance date: 02/04/2018

Series Title: Advances in Experimental Medicine and Biology

Publisher: Springer

Place Published: Cham

URL: https://doi.org/10.1007/978-3-031-44087-8_40

DOI: 10.1007/978-3-031-44087-8_40

PubMed id: 38884742

Library holdings: Search Newcastle University Library for this item

ISBN: 9783031440861


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