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Lookup NU author(s): Dr Ellie Gill, Dr Simon BamforthORCiD
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© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG. During normal cardiovascular development, the outflow tract becomes septated and rotates so that the separate aorta and pulmonary trunk are correctly aligned with the left and right ventricles, respectively. However, when this process goes wrong, the aorta and pulmonary trunk are incorrectly positioned, resulting in oxygenated blood being directly returned to the lungs, with deoxygenated blood being delivered to the systemic circulation. This is termed transposition of the great arteries (TGA). The precise etiology of TGA is not known, but the use of animal models has elucidated that genes involved in determination of the left- embryonic body axis play key roles. Other factors such as retinoic acid levels are also crucial. This chapter reviews the animal models presenting with TGA that have been generated by genetic manipulation or with exogenous agents.
Author(s): Gill E, Bamforth SD
Editor(s): Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas
Publication type: Book Chapter
Publication status: Published
Book Title: Congenital Heart Diseases: The Broken Heart. Clinical Features, Human Genetics and Molecular Pathways
Year: 2024
Volume: 1441
Pages: 683-696
Online publication date: 18/06/2024
Acceptance date: 02/04/2018
Series Title: Advances in Experimental Medicine and Biology
Publisher: Springer
Place Published: Cham
URL: https://doi.org/10.1007/978-3-031-44087-8_40
DOI: 10.1007/978-3-031-44087-8_40
PubMed id: 38884742
Library holdings: Search Newcastle University Library for this item
ISBN: 9783031440861