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Molecular Pathways and Animal Models of Semilunar Valve and Aortic Arch Anomalies

Lookup NU author(s): Dr Ellie Gill, Dr Simon BamforthORCiD

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Abstract

© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG. The great arteries of the vertebrate carry blood from the heart to the systemic circulation and are derived from the pharyngeal arch arteries. In higher vertebrates, the pharyngeal arch arteries are a symmetrical series of blood vessels that rapidly remodel during development to become the asymmetric aortic arch arteries carrying oxygenated blood from the left ventricle via the outflow tract. At the base of the aorta, as well as the pulmonary trunk, are the semilunar valves. These valves each have three leaflets and prevent the backflow of blood into the heart. During development, the process of aortic arch and valve formation may go wrong, resulting in cardiovascular defects, and these may, at least in part, be caused by genetic mutations. In this chapter, we will review models harboring genetic mutations that result in cardiovascular defects affecting the great arteries and the semilunar valves.


Publication metadata

Author(s): Gill E, Bamforth SD

Editor(s): Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart. Clinical Features, Human Genetics and Molecular Pathways

Year: 2024

Volume: 1441

Pages: 777-796

Online publication date: 18/06/2024

Acceptance date: 02/04/2018

Series Title: Advances in Experimental Medicine and Biology

Publisher: Springer

Place Published: Cham

URL: https://doi.org/10.1007/978-3-031-44087-8_46

DOI: 10.1007/978-3-031-44087-8_46

PubMed id: 38884748

Library holdings: Search Newcastle University Library for this item

ISBN: 9783031440861


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