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Lookup NU author(s): Dr Ellie Gill, Dr Simon BamforthORCiD
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© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG. The great arteries of the vertebrate carry blood from the heart to the systemic circulation and are derived from the pharyngeal arch arteries. In higher vertebrates, the pharyngeal arch arteries are a symmetrical series of blood vessels that rapidly remodel during development to become the asymmetric aortic arch arteries carrying oxygenated blood from the left ventricle via the outflow tract. At the base of the aorta, as well as the pulmonary trunk, are the semilunar valves. These valves each have three leaflets and prevent the backflow of blood into the heart. During development, the process of aortic arch and valve formation may go wrong, resulting in cardiovascular defects, and these may, at least in part, be caused by genetic mutations. In this chapter, we will review models harboring genetic mutations that result in cardiovascular defects affecting the great arteries and the semilunar valves.
Author(s): Gill E, Bamforth SD
Editor(s): Silke Rickert-Sperling, Robert G. Kelly, Nikolaus Haas
Publication type: Book Chapter
Publication status: Published
Book Title: Congenital Heart Diseases: The Broken Heart. Clinical Features, Human Genetics and Molecular Pathways
Year: 2024
Volume: 1441
Pages: 777-796
Online publication date: 18/06/2024
Acceptance date: 02/04/2018
Series Title: Advances in Experimental Medicine and Biology
Publisher: Springer
Place Published: Cham
URL: https://doi.org/10.1007/978-3-031-44087-8_46
DOI: 10.1007/978-3-031-44087-8_46
PubMed id: 38884748
Library holdings: Search Newcastle University Library for this item
ISBN: 9783031440861