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Standardised definitions and diagnostic criteria for extranodal extension detected on histopathological examination in head and neck cancer: Head and Neck Cancer International Group consensus recommendations

Lookup NU author(s): Dr Max RobinsonORCiD

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Abstract

© 2024 Elsevier LtdDetection of extranodal extension on histopathology in surgically treated head and neck squamous cell carcinoma indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation, and reporting of histology detected extranodal extension, which has contributed to conflicting evidence in the literature, and likely clinical inconsistency. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts representing 15 national clinical research groups to generate consensus recommendations for histology detected extranodal extension diagnostic criteria. The expert panel strongly agreed on terminology and diagnostic features for histology detected extranodal extension and soft tissue metastasis. Moreover, the panel reached consensus on reporting of histology detected extranodal extension and on nodal sampling. These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a crucial development towards standardised diagnosis and reporting of histology detected extranodal extension, and more accurate data collection and analysis.

Publication metadata

Author(s): Abou-Foul AK, Henson C, Chernock RD, Huang SH, Lydiatt WM, McDowell L, O'Sullivan B, Perez-Ordonez B, Robinson M, Nankivell PC, Ruiz-Bravo E, Chiosea SI, Green TM, Hunter KD, Hwang JS, Koljenovic S, Koppes SA, Larsen SR, Lo AWI, Costes-Martineau V, Mittal N, Mori T, Nagao T, Panayiotides IG, Pinto CAL, Scheckenbach K, Seethala RR, Ulhoi BP, Vingiani A, Zhang Y, Yom SS, Mehanna H

Publication type: Review

Publication status: Published

Journal: The Lancet Oncology

Year: 2024

Volume: 25

Issue: 7

Pages: e286-e296

Print publication date: 01/07/2024

Acceptance date: 02/04/2024

ISSN (print): 1470-2045

ISSN (electronic): 1474-5488

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/S1470-2045(24)00143-8

DOI: 10.1016/S1470-2045(24)00143-8

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