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Under what circumstances can chemical oxidation processes effectively degrade antibiotics resistance genes? Evidence from meta-analysis

Lookup NU author(s): Dr Evangelos Petropoulos

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Abstract

© 2024 Elsevier LtdAntibiotics resistance genes (ARGs) is a global concern impairing public health and environmental quality. Chemical oxidation processes (COPs) can generate free radicals, to oxo-degrade DNA and limit ARGs spread. After a rigorous collation of literature related to COPs degrading ARGs, a meta-analysis was performed to evaluate five conventional COPs (photocatalysis, fenton-like oxidation, persulfate oxidation, ozone oxidation, and chlorination) in removing ARGs in aqueous environments. A random effects model was used to estimate the 95 % confidence intervals (95 % CI) and the amount of heterogeneity (R2) which signifies the influential capacity of specific factors. The results confirmed that COPs significantly diminish ARGs (95 % CI:-3.61, −3.17) with the subgroup analysis indicating that based heterogeneity (6.14 %) the type of COPs is crucial on ARGs removal performance. Specifically, Fenton delivers the highest oxidation effect (95 % CI: −6.06, −4.85). The type and location (intracellular, extracellular, or total) of such genes also influence removal efficiency (R2 of 7.45 % and 0.91 % respectively). Other factors, pH, COD content, temperature, oxidizer dosage, and reaction time were also found somewhat influential based on R2 (10.31 %, 3.36 %, 2.08 %, 0.70 %, and 0.26 % respectively). Overall, this meta-analysis summarizes on a quantitative manner the influential factors affecting ARGs pollution control via COPs in aqueous environments.

Publication metadata

Author(s): Ren Z, Yang B, Petropoulos E, Liu H, Hou P, He S, Ma X, Zhang J, Xue L, Yang L

Publication type: Article

Publication status: Published

Journal: Journal of Environmental Chemical Engineering

Year: 2024

Volume: 12

Issue: 5

Print publication date: 01/10/2024

Online publication date: 20/06/2024

Acceptance date: 19/06/2024

ISSN (print): 2213-2929

ISSN (electronic): 2213-3437

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.jece.2024.113385

DOI: 10.1016/j.jece.2024.113385

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