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Lookup NU author(s): Dr Othman AlmusaimiORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Peptides exhibit significant specificity and effective interaction with therapeutic targets, positioning themselves as key players in the global pharmaceutical market. They offer potential treatments for a wide range of diseases, including those that pose significant challenges. Notably, the peptide trofinetide (Daybue) marked a groundbreaking achievement by providing the first-ever cure for Rett syndrome, and several peptides have secured FDA approval as first-in-class medications. Furthermore, peptides are expanding their presence in areas traditionally dominated by either small or large molecules. A noteworthy example is the FDA approval of motixafortide (Aphexda) as the first peptide-based chemokine antagonist. Here, the focus will be on the analysis of FDA-approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, central nervous system diseases, and various other intriguing classes addressing conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia, among others. The review will explore the chemical structures of the peptides, their indications and modes of action, the developmental trajectory, and potential adverse effects.
Author(s): Al Musaimi O
Publication type: Article
Publication status: Published
Journal: Journal of Peptide Science
Year: 2024
Issue: ePub ahead of Print
Online publication date: 17/06/2024
Acceptance date: 17/05/2024
Date deposited: 16/07/2024
ISSN (print): 1075-2617
ISSN (electronic): 1099-1387
Publisher: Wiley-Blackwell Publishing Ltd.
URL: https://onlinelibrary.wiley.com/doi/10.1002/psc.3627
DOI: 10.1002/psc.3627
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