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Genitourinary infection and gastroschisis: A systematic review and meta-analysis

Lookup NU author(s): Raya Vinogradov, Dr Malcolm Moffat, Professor Judith RankinORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2024 The Author(s). Birth Defects Research published by Wiley Periodicals LLC.Background: Gastroschisis is a congenital anomaly of the umbilical ring with increasing prevalence, especially amongst younger mothers. There is increasing evidence that exposure to genitourinary infections (GUTI) may play an important role in the etiology of gastroschisis. This systematic review and meta-analysis aimed to identify, appraise, and summarize the literature on exposure to GUTI and gastroschisis. Methods: Six electronic databases (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane Library electronic databases, and Prospero) were searched using a comprehensive search strategy. Citations and cited articles for all included studies were searched. Peer-reviewed, quantitative studies reporting an association of urinary tract infections (UTI) and/or sexually transmitted infections (STI) with gastroschisis were included. Prospero registration CRD42022377420. Results: A total of 2392 papers were identified via the searches of which 15 met our inclusion criteria and were included after title and abstract and full text screening. The study period for included studies ranged from 1995 to 2016, most were from the USA. Four studies considering exposure to STIs and five to UTIs were eligible to progress to meta-analysis. Meta-analysis identified a significantly increased risk of gastroschisis in association with periconceptional exposure to UTI [OR 1.54 (95% CI 1.29, 1.8)], STI [OR 1.4 (95% CI 1.01, 1.79)]. Conclusions: Periconceptional exposure to GUTI is associated with an increased risk of gastroschisis. The prevention and timely treatment of GUTI amongst women of childbearing age may help to reduce the occurrence of gastroschisis.


Publication metadata

Author(s): Vinogradov R, Muthupunnackal A, Moffat M, Rankin J

Publication type: Article

Publication status: Published

Journal: Birth Defects Research

Year: 2024

Volume: 116

Issue: 7

Print publication date: 01/07/2024

Online publication date: 30/06/2024

Acceptance date: 11/06/2024

Date deposited: 16/07/2024

ISSN (print): 2472-1727

ISSN (electronic): 2472-1727

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/bdr2.2377

DOI: 10.1002/bdr2.2377

Data Access Statement: Data are extracted from published papers therefore a data availability statement is not applicable

PubMed id: 38946111


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Funding

Funder referenceFunder name
Applied Research Collaboration (ARC)
National Institute for Health and Care Research (NIHR)
North East and North Cumbria (NENC) (APF2209)

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