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Lookup NU author(s): Raya Vinogradov, Dr Malcolm Moffat, Professor Judith Rankin
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Birth Defects Research published by Wiley Periodicals LLC.Background: Gastroschisis is a congenital anomaly of the umbilical ring with increasing prevalence, especially amongst younger mothers. There is increasing evidence that exposure to genitourinary infections (GUTI) may play an important role in the etiology of gastroschisis. This systematic review and meta-analysis aimed to identify, appraise, and summarize the literature on exposure to GUTI and gastroschisis. Methods: Six electronic databases (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane Library electronic databases, and Prospero) were searched using a comprehensive search strategy. Citations and cited articles for all included studies were searched. Peer-reviewed, quantitative studies reporting an association of urinary tract infections (UTI) and/or sexually transmitted infections (STI) with gastroschisis were included. Prospero registration CRD42022377420. Results: A total of 2392 papers were identified via the searches of which 15 met our inclusion criteria and were included after title and abstract and full text screening. The study period for included studies ranged from 1995 to 2016, most were from the USA. Four studies considering exposure to STIs and five to UTIs were eligible to progress to meta-analysis. Meta-analysis identified a significantly increased risk of gastroschisis in association with periconceptional exposure to UTI [OR 1.54 (95% CI 1.29, 1.8)], STI [OR 1.4 (95% CI 1.01, 1.79)]. Conclusions: Periconceptional exposure to GUTI is associated with an increased risk of gastroschisis. The prevention and timely treatment of GUTI amongst women of childbearing age may help to reduce the occurrence of gastroschisis.
Author(s): Vinogradov R, Muthupunnackal A, Moffat M, Rankin J
Publication type: Article
Publication status: Published
Journal: Birth Defects Research
Year: 2024
Volume: 116
Issue: 7
Print publication date: 01/07/2024
Online publication date: 30/06/2024
Acceptance date: 11/06/2024
Date deposited: 16/07/2024
ISSN (print): 2472-1727
ISSN (electronic): 2472-1727
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/bdr2.2377
DOI: 10.1002/bdr2.2377
PubMed id: 38946111
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