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Lookup NU author(s): Raasti Naseem, Nicola HoweORCiD, Dr Cameron WilliamsORCiD, Dr Sara Pretorius, Dr Kile GreenORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2024 [The Author]A scoping review methodological framework formed the basis of this review. A search of two electronic databases captured relevant literature published from 2013. 1184 articles were screened, 200 of which met inclusion criteria. Included studies were categorised as tests for either respiratory infections OR pulmonary exacerbations. Data were extracted to ascertain test type, sample type, and indication of use for each test type. For infection, culture is the most common testing method, particularly for bacterial infections, whereas PCR is utilised more for the diagnosis of viral infections. Spirometry tests, indicating lung function, facilitate respiratory infection diagnoses. There is no clear definition of what an exacerbation is in persons with CF. A clinical checklist with risk criteria can determine if a patient is experiencing an exacerbation event, however the diagnosis is clinician-led and will vary between individuals. Fuchs criteria are one of the most frequently used tests to assess signs and symptoms of exacerbation in persons with CF. This scoping review highlights the development of home monitoring tests to facilitate earlier and easier diagnoses, and the identification of novel biomarkers for indication of infections/exacerbations as areas of current research and development. Research is particularly prevalent regarding exhaled breath condensate and volatile organic compounds as an alternative sampling/biomarker respectively for infection diagnosis. Whilst there are a wide range of tests available for diagnosing respiratory infections and/or exacerbations, these are typically used clinically in combination to ensure a rapid, accurate diagnosis which will ultimately benefit both the patient and clinician.
Author(s): Naseem R, Howe N, Williams CJ, Pretorius S, Green K
Publication type: Review
Publication status: Published
Journal: Respiratory Investigation
Year: 2024
Volume: 62
Issue: 5
Pages: 817-831
Print publication date: 01/09/2024
Online publication date: 17/07/2024
Acceptance date: 06/07/2024
ISSN (print): 2212-5345
ISSN (electronic): 2212-5353
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.resinv.2024.07.005
DOI: 10.1016/j.resinv.2024.07.005
Data Access Statement: Data used in this publication is available from the corresponding author upon reasonable request.
