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Lookup NU author(s): Dr Jie ZhangORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The objective of this study is the development of innovative nanocurcumin-based formulations designed for the treatment and prevention of oxidative stress and diabetes. Nanocurcumin was obtained through a micronization process and subsequently encapsulated within biopolymers derived from corn starch and fenugreek mucilage, achieving encapsulation rates of 75% and 85%, respectively. Subsequently, the encapsulated nanocurcumin was utilized in the formulation of sugarfree syrups based on Stevia rebaudiana Bertoni. The stability of the resulting formulations was assessed by monitoring particle size distribution and zeta potential over a 25-day period. Dynamic light scattering(DLS) revealed a particle size of 119.9 nm for the fenugreek mucilage-based syrup (CURF) and 117 nm for the corn starch-based syrup (CURA), with polydispersity indices PDIs of 0.509 and 0.495, respectively. The dissolution rates of the encapsulated nanocurcumin were significantly enhanced, showing a 67% improvement in CURA and a 70% enhancement in CURF compared with crude curcumin (12.82%). Both formulations demonstrated excellent antioxidant activity, as evidenced by polyphenol quantification using the 2.2-diphenyl 1-pycrilhydrazyl (DPPH) assay. In the evaluation of antidiabetic activity conducted onWistar rats, a substantial reduction in fasting blood sugar levelsfrom 392 to 187 mg/mL was observed. The antioxidant properties of CURF in reducing oxidative stress were clearly demonstrated by a macroscopic observation of the rats’ livers, including their color and appearance.
Author(s): Ferradj S, Yahoum MM, Mounia R, Nabi I, Toumi S, Lefnaoui S, AZiane-Zafour AH, Touzout N, Tahraoui H, Mihoub A, Seleiman MF, Ali N, Zhang J, Amrane A
Publication type: Article
Publication status: Published
Journal: Nanomaterials
Year: 2024
Volume: 14
Issue: 13
Online publication date: 27/06/2024
Acceptance date: 25/06/2024
Date deposited: 21/08/2024
ISSN (electronic): 2079-4991
Publisher: MDPI
URL: https://doi.org/10.3390/nano14131105
DOI: 10.3390/ nano14131105
Data Access Statement: The data presented in this study are available in the manuscript.
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