Browse by author
Lookup NU author(s): Professor John Mathers
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024.It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. This study aimed to investigate if the association between alcohol consumption and severe ALD is modified by diet. This prospective study included 303,269 UK Biobank participants. Alcohol consumption and diet were self-reported. The diet score was created from 4 items selected using LASSO. Cox proportional hazard model showed that the diet score was monotonically associated with severe ALD risk, adjusted for sociodemographics, lifestyle factors, and alcohol consumption. Relative excess risk due to interaction analysis indicated that having a higher ALD diet score and a higher alcohol consumption simultaneously confers to 2.44 times (95% CI: 1.06-3.83) higher risk than the sum of excess risk of each factor. In this work, we show that people who have a poor diet might be more susceptible to severe ALD due to alcohol consumption.
Author(s): Petermann-Rocha F, Zhou Z, Mathers JC, Celis-Morales C, Raubenheimer D, Sattar N, Pell JP, Forrest E, Ho FK
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2024
Volume: 15
Issue: 1
Online publication date: 11/08/2024
Acceptance date: 05/08/2024
Date deposited: 20/08/2024
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/s41467-024-51314-9
DOI: 10.1038/s41467-024-51314-9
Data Access Statement: Data cannot be shared directly due to the material transfer agreement from UK Biobank. All UK Biobank information is available online on the webpage https://www.ukbiobank.ac.uk/. Data access is available through applications. This research was conducted using the application number 71392.
Altmetrics provided by Altmetric
