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Lookup NU author(s): Dr Annette Meeson
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2024 The Author(s).Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirectional differentiation, and infinite proliferation. They have been shown to play an important role in tumor growth, metastasis, drug resistance, and angiogenesis. Ovarian cancer side population (SP) cells, a type of CSC, have been shown to play roles in tumor formation, colony formation, xenograft tumor formation, ascites formation, and tumor metastasis. The rapid progression of tumor angiogenesis is necessary for tumor growth; however, many of the mechanisms driving this process are unclear as is the contribution of CSCs. The aim of this review was to document the current state of knowledge of the molecular mechanism of ovarian cancer stem cells (OCSCs) in regulating tumor angiogenesis.
Author(s): Pan Y, Yang X, Chen M, Shi K, Lyu Y, Meeson AP, Lash GE
Publication type: Review
Publication status: Published
Journal: Medical Principles and Practice
Year: 2024
Pages: 1-11
Online publication date: 26/07/2024
Acceptance date: 03/06/2024
ISSN (print): 1011-7571
ISSN (electronic): 1423-0151
Publisher: S. Karger AG
URL: https://doi.org/10.1159/000539642
DOI: 10.1159/000539642
PubMed id: 39068919
