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Role of Cancer Side Population Stem Cells in Ovarian Cancer Angiogenesis

Lookup NU author(s): Dr Annette Meeson

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

© 2024 The Author(s). Ovarian cancer is one of the most common gynecologic malignancies. Recurrence and metastasis often occur after treatment, and it has the highest mortality rate of all gynecological tumors. Cancer stem cells (CSCs) are a small population of cells with the ability of self-renewal, multidirectional differentiation, and infinite proliferation. They have been shown to play an important role in tumor growth, metastasis, drug resistance, and angiogenesis. Ovarian cancer side population (SP) cells, a type of CSC, have been shown to play roles in tumor formation, colony formation, xenograft tumor formation, ascites formation, and tumor metastasis. The rapid progression of tumor angiogenesis is necessary for tumor growth; however, many of the mechanisms driving this process are unclear as is the contribution of CSCs. The aim of this review was to document the current state of knowledge of the molecular mechanism of ovarian cancer stem cells (OCSCs) in regulating tumor angiogenesis.

Publication metadata

Author(s): Pan Y, Yang X, Chen M, Shi K, Lyu Y, Meeson AP, Lash GE

Publication type: Review

Publication status: Published

Journal: Medical Principles and Practice

Year: 2024

Volume: 33

Issue: 5

Pages: 403-413

Print publication date: 01/10/2024

Online publication date: 26/07/2024

Acceptance date: 03/06/2024

ISSN (print): 1011-7571

ISSN (electronic): 1423-0151

Publisher: S. Karger AG

URL: https://doi.org/10.1159/000539642

DOI: 10.1159/000539642

PubMed id: 39068919

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