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Lookup NU author(s): Dr Petros PerrosORCiD
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© Springer Nature Limited 2024. Persistent symptoms are common in the general population and even more so in people with hypothyroidism. When symptoms are unexplained and brought to medical attention, they can be referred to as medically not yet explained symptoms (MNYES), a term preferred to other descriptors by patients, care-givers and experts. MNYES might be neglected by endocrinologists or misattributed to hypothyroidism. Awareness of MNYES could open up more effective and less harmful interventions for patients who present to endocrinologists with unexplained symptoms than costly over-investigations and over-treatment with thyroid hormones (such as levothyroxine and liothyronine). The role of the endocrinologist is to recognize and acknowledge that MNYES could be underlying a patient’s presentation, to communicate effectively with the patient and others involved in the patient’s care, to apply a ‘two-track approach’ in management by paying equal attention to physical and psychosocial contributors, and to collaborate with other relevant health professionals. Categorization of patients into levels of risk for symptom deterioration helps in selecting suitable therapies. Effective management of MNYES demands time, training, expertise and resources.
Author(s): Hegedus L, Van Der Feltz-Cornelis CM, Papini E, Nagy EV, Weetman AP, Perros P
Publication type: Article
Publication status: Published
Journal: Nature Reviews Endocrinology
Year: 2024
Volume: 20
Pages: 685–693
Print publication date: 01/11/2024
Online publication date: 13/08/2024
Acceptance date: 11/07/2024
ISSN (print): 1759-5029
ISSN (electronic): 1759-5037
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41574-024-01022-7
DOI: 10.1038/s41574-024-01022-7
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