ePrints

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Lookup NU author(s): João Novo, Lucy Gee, Professor Thomas von Zglinicki, Dr Diana JurkORCiD

Downloads

• Published version [.pdf]

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.

Publication metadata

Author(s): Novo JP, Gee L, Caetano CA, Tome I, Vilaca A, von Zglinicki T, Moreira IS, Jurk D, Rosa S, Ferreira L

Publication type: Article

Publication status: Published

Journal: Aging Cell

Year: 2024

Volume: 23

Issue: 9

Print publication date: 01/09/2024

Online publication date: 15/08/2024

Acceptance date: 26/06/2024

Date deposited: 27/08/2024

ISSN (print): 1474-9718

ISSN (electronic): 1474-9726

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1111/acel.14270

DOI: 10.1111/acel.14270

Data Access Statement: The data that support the findings of this study are available fromthe corresponding author upon reasonable request.

Altmetrics

Funding

Share