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Lookup NU author(s): Dr Lauren Beck, Professor Janet Berrington, Professor Christopher StewartORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024.Impact: Meta-analysis of probiotic administration to very preterm or very low birthweight (VP/VLBW) infants shows reduced risk of necrotising enterocolitis (NEC). Separately reported outcomes for extremely preterm infants (<28 weeks) or extremely low birth weight infants (<1000 g) (EP/ELBW) are lacking meaning some clinicians do not administer probiotics to EP/ELBW infants despite their high risk of NEC. We present data showing the gut microbiome is impacted in EP/ELBW infants in a similar manner to VP/VLBW infants, suggesting that risk reduction for necrotising enterocolitis that is microbiome driven will also be seen in EP/ELBW infants, making probiotic administration beneficial.
Author(s): Beck LC, Berrington JE, Stewart CJ
Publication type: Article
Publication status: Published
Journal: Pediatric Research
Year: 2024
Pages: epub ahead of print
Online publication date: 25/08/2024
Acceptance date: 12/08/2024
Date deposited: 02/09/2024
ISSN (print): 0031-3998
ISSN (electronic): 1530-0447
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41390-024-03520-w
DOI: 10.1038/s41390-024-03520-w
Data Access Statement: Suitably anonymised data may be available on reasonable request. All metagenomic sequencing data generated and analysed in the present study have been deposited in the European Nucleotide Archive under study accession no. PRJEB49383.
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