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Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Lookup NU author(s): Professor Marieke Emonts-le ClercqORCiD

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Author(s): Patel H, Carter MJ, Jackson H, Powell O, Fish M, Terranova-Barberio M, Spada F, Petrov N, Wellman P, Darnell S, Mustafa S, Todd K, Bishop C, Cohen JM, Kenny J, van den Berg S, Sun T, Davis F, Jennings A, Timms E, Thomas J, Nyirendra M, Nichols S, Estamiana Elorieta L, D'Souza G, Wright V, De T, Hadgood-Coote D, Ramnarayan P, Tissières P, Whittaker E, Herberg J, Cunnington A, Kaforou M, Ellis R, Malim MH, Tibby M, ShankarHari M, Levin M, DIAMONDS consortium, Emonts M

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2024

Volume: 15

Online publication date: 19/09/2024

Acceptance date: 22/08/2024

Date deposited: 26/09/2024

ISSN (electronic): 2041-1723

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/s41467-024-52246-0

DOI: 10.1038/s41467-024-52246-0

Data Access Statement: The gene counts and patient metadata for the Transcriptomic Cohort are available at ArrayExpress under accession code E-MTAB-11671. The merged and normalized dataset used for the analysis of the discovery dataset is available in ArrayExpress under accession code E-MTAB-12793. The raw FCS files for Supplementary Fig. 10 are available on ImmPort under accession code SDY2735. Source data are provided with this paper. Code availability Code for the bioinformatic analyses of mass cytometry data is available at: https://github.com/michaeljamescarter/SIFIC. Code for the analysis of RNA-seq data is available at: https://github.com/PIDBG/misc_transcriptomic_signature29. A permanent repository for the code is at the https://doi.org/10.5281/zenodo.12790924.

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