Toggle Main Menu Toggle Search

Open Access padlockePrints

Cross-Sectional and Prospective Associations between Parkinsonism and Parkinson's Disease with Frailty in Latin America

Lookup NU author(s): Dr Nusrat KhanORCiD, Professor Matthew Prina

Downloads


Licence

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Background: Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America. Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and PD with frailty in a large multi-country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population. Methods: 12,865 older adults (aged ≥65 years) from the 10/66 population-based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross-sectional association between parkinsonism/PD with baseline frailty. Individual country analyses were combined via fixed-effect meta-analysis. In non-frail participants who were followed up for 4 years, Cox proportional hazards regression models assessed the prospective association between parkinsonism/PD with incident frailty accounting for competing risk of mortality. Results: At baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87–3.31), 2.42 (95% CIs 1.80–3.25), and 1.57 (95% CIs 1.16–2.21), and cause-specific hazard ratios were 1.66 (95% CIs 1.07–2.56), 1.78 (95% CIs 1.05–3.03), and 1.58 (95% CIs 0.91–2.74). Similar results were found for parkinsonism. Conclusion: Parkinsonism and PD were cross-sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.


Publication metadata

Author(s): Kim DJ, Khan N, Llibre-Rodriguez JJ, Jiang M, Rodriguez-Salgado AM, Acosta I, Sosa AL, Acosta D, Jimenez-Velasquez IZ, Guerra M, Salas A, Sanchez ND, Lopez-Contreras R, Hesse H, Tanner C, Llibre-Guerra JJ, Prina M

Publication type: Article

Publication status: Published

Journal: Movement Disorders Clinical Practice

Year: 2024

Pages: epub ahead of print

Online publication date: 20/09/2024

Acceptance date: 04/09/2024

Date deposited: 02/10/2024

ISSN (electronic): 2330-1619

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/mdc3.14214

DOI: 10.1002/mdc3.14214

Data Access Statement: The data supporting the findings of this study are derived from the 10/66 Dementia Research Group’s population-based study. Data are available upon reasonable request to the 10/66 Dementia Research Group and subject to the approval of the respective data governance committees. Data requests can be submitted via the Alzheimer’s Disease Data Initiative (ADDI) platform


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
Alzheimer’s Association (24HPE-1287320)
GR080002
Michael J. Fox Foundation (MJFF-020770)
Wellcome Trust Health Consequences of Population Change Programme (GR066133)
US Alzheimer’s Association
World Health Organization

Share