Browse by author
Lookup NU author(s): Dr Nusrat KhanORCiD, Professor Matthew Prina
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Background: Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America. Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and PD with frailty in a large multi-country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population. Methods: 12,865 older adults (aged ≥65 years) from the 10/66 population-based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross-sectional association between parkinsonism/PD with baseline frailty. Individual country analyses were combined via fixed-effect meta-analysis. In non-frail participants who were followed up for 4 years, Cox proportional hazards regression models assessed the prospective association between parkinsonism/PD with incident frailty accounting for competing risk of mortality. Results: At baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87–3.31), 2.42 (95% CIs 1.80–3.25), and 1.57 (95% CIs 1.16–2.21), and cause-specific hazard ratios were 1.66 (95% CIs 1.07–2.56), 1.78 (95% CIs 1.05–3.03), and 1.58 (95% CIs 0.91–2.74). Similar results were found for parkinsonism. Conclusion: Parkinsonism and PD were cross-sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.
Author(s): Kim DJ, Khan N, Llibre-Rodriguez JJ, Jiang M, Rodriguez-Salgado AM, Acosta I, Sosa AL, Acosta D, Jimenez-Velasquez IZ, Guerra M, Salas A, Sanchez ND, Lopez-Contreras R, Hesse H, Tanner C, Llibre-Guerra JJ, Prina M
Publication type: Article
Publication status: Published
Journal: Movement Disorders Clinical Practice
Year: 2024
Pages: epub ahead of print
Online publication date: 20/09/2024
Acceptance date: 04/09/2024
Date deposited: 02/10/2024
ISSN (electronic): 2330-1619
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/mdc3.14214
DOI: 10.1002/mdc3.14214
Data Access Statement: The data supporting the findings of this study are derived from the 10/66 Dementia Research Group’s population-based study. Data are available upon reasonable request to the 10/66 Dementia Research Group and subject to the approval of the respective data governance committees. Data requests can be submitted via the Alzheimer’s Disease Data Initiative (ADDI) platform
Altmetrics provided by Altmetric