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Lookup NU author(s): Dr Andrea Masi, Dr Lauren Beck, Dr John Perry, Dr Claire Granger, Dr Greg YoungORCiD, Professor Nicholas EmbletonORCiD, Professor Janet Berrington, Professor Christopher StewartORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. Necrotizing enterocolitis (NEC) is a severe intestinal disease of very preterm infants with mother's own milk (MOM) providing protection, but the contribution of the MOM microbiota to NEC risk has not been explored. Here, we analyze MOM of 110 preterm infants (48 NEC, 62 control) in a cross-sectional study. Breast milk contains viable bacteria, but there is no significant difference in MOM microbiota between NEC and controls. Integrative analysis between MOM microbiota, human milk oligosaccharides (HMOs), and the infant gut microbiota shows positive correlations only between Acinetobacter in the infant gut and Acinetobacter and Staphylococcus in MOM. This study suggests that NEC protection from MOM is not modulated through the MOM microbiota. Thus, "'restoring" the MOM microbiota in donor human milk is unlikely to reduce NEC, and emphasis should instead focus on increasing fresh maternal human milk intake and researching different therapies for NEC prevention.
Author(s): Masi AC, Beck LC, Perry JD, Granger CL, Hiorns A, Young GR, Bode L, Embleton ND, Berrington JE, Stewart CJ
Publication type: Article
Publication status: Published
Journal: Cell Reports Medicine
Year: 2024
Volume: 5
Issue: 9
Print publication date: 17/09/2024
Online publication date: 30/08/2024
Acceptance date: 08/08/2024
Date deposited: 01/10/2024
ISSN (electronic): 2666-3791
Publisher: Cell Press
URL: https://doi.org/10.1016/j.xcrm.2024.101708
DOI: 10.1016/j.xcrm.2024.101708
Data Access Statement: All sequencing data generated and analyzed in this study have been deposited in the European Nucleotide Archive. The MOM microbiota data and corresponding metadata are available under study accession number PRJEB72536. The infant gut microbiome data and corresponding metadata are available under study accession number PRJEB39610. This study used pre-existing software and did not generate new custom code. Any additional information required to reanalyse the data reported in this paper is available from the lead contact (Christopher Stewart, christopher.stewart@newcastle.ac.uk) upon request.
PubMed id: 39216480
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