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HIT4HYPOS Continuous Glucose Monitoring Data Analysis: The Effects of High-Intensity Interval Training on Hypoglycemia in People With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

Lookup NU author(s): Dr Daniel WestORCiD

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Abstract

© 2024 Diabetes Technology Society.Aims: To assess the impact of high-intensity interval training (HIIT) on hypoglycemia frequency and duration in people with type 1 diabetes (T1D) with impaired awareness of hypoglycemia (IAH). Methods: Post hoc analysis of four weeks of continuous glucose monitoring (CGM) data from HIT4HYPOS; a parallel-group study comparing HIIT + CGM versus no exercise + CGM in 18 participants with T1D and IAH. Results: When compared with those participating individuals not exercising, HIIT did not increase total hypoglycemia frequency, THypo(L1) 1.44 [1.00-2.77]% versus 2.53 [1.46-4.23]%; P =.335, THypo(L2) 0.25 [0.09-0.37]% versus 0.45 [0.20-0.78]%; P =.146, HIIT + CGM versus CGM, respectively, rate (EventPerWeekHypo 5.30 [3.35-8.27] #/week vs 7.45 [3.54-10.81] #/week, P =.340) or duration (DurationHypo 33.33 [27.60-39.10] minutes vs 39.56 [31.00-48.38] minutes; P =.219, HIIT + CGM vs CGM, respectively). There was a reduction in nocturnal hypoglycemia in those who carried out HIIT, THypo(L1) 0.50 [0.13-0.97]% versus 2.45 [0.77-4.74]%; P =.076; THypo(L2) 0.00 [0.00-0.03]% versus 0.49 [0.13-0.74]%; P =.006, HIIT + CGM versus CGM, respectively. Conclusions/interpretation: Based on CGM data collected from a real-world study of four weeks of HIIT versus no exercise in individuals with T1D and IAH, we conclude that HIIT does not increase hypoglycemia, and in fact reduces exposure to nocturnal hypoglycemia.

Publication metadata

Author(s): Farrell CM, Cappon G, West DJ, Facchinetti A, McCrimmon RJ

Publication type: Article

Publication status: Published

Journal: Journal of Diabetes Science and Technology

Year: 2024

Pages: epub ahead of print

Online publication date: 23/09/2024

Acceptance date: 02/04/2018

ISSN (print): 1932-2968

ISSN (electronic): 1932-2968

Publisher: Sage Publications Inc.

URL: https://doi.org/10.1177/19322968241273845

DOI: 10.1177/19322968241273845

PubMed id: 39311445

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