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Lookup NU author(s): Dr Christopher ThorntonORCiD, Dr Mariella Panagiotopoulou, Sarah Gascoigne, Guillermo BesneORCiD, Professor Peter TaylorORCiD, Professor Yujiang WangORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the unique opportunity of long-term, continuous intracranially recorded EEG from 38 patients (totalling 6338 hours) to delineate circadian (daily) and ultradian (minute to hourly) rhythms in different brain regions. We show that functional circadian and ultradian rhythms are diminished in pathological tissue, independent of regional variations. We further demonstrate that these diminished rhythms are persistent in time, regardless of load or occurrence of pathological events. These findings provide evidence that brain pathology is functionally associated with persistently diminished chronobiological rhythms in vivo in humans, independent of regional variations or pathological events. Future work interacting with, and restoring, these modulatory chronobiological rhythms may allow for novel therapies.
Author(s): Thornton C, Panagiotopoulou M, Chowdhury FA, Diehl B, Duncan JS, Gascoigne SJ, Besne G, McEvoy AW, Miserocchi A, Smith BC, de Tisi J, Taylor PN, Wang Y
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2024
Volume: 15
Online publication date: 02/10/2024
Acceptance date: 19/09/2024
Date deposited: 14/10/2024
ISSN (electronic): 2041-1723
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41467-024-52769-6
DOI: 10.1038/s41467-024-52769-6
Data Access Statement: Source data are provided with this paper. Data used is available at: https://zenodo.org/record/8289342. Code availability: All analysis was performed using Python (version 3.8) and MATLAB (version R2023a). Code used is available at: https://github.com/cnnp-lab/DiminishedRhythmsPathology.
PubMed id: 39358327
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