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Lookup NU author(s): Emerita Professor Zofia Chrzanowska-LightowlersORCiD, Emeritus Professor Robert Lightowlers
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. The vast majority of oxygen-utilizing eukaryotes need to express their own mitochondrial genome, mtDNA, to survive. In comparison to size of their nuclear genome, mtDNA is minimal, even in the most exceptional examples. Having evolved from bacteria in an endosymbiotic event, it might be expected that the process of mtDNA expression would be relatively simple. The aim of this short review is to illustrate just how wrong this assumption is. The production of functional mitochondrial RNA across species evolved in many directions. Organelles use a dizzying array of RNA processing, modifying, editing, splicing and maturation events that largely require the import of nuclear-encoded proteins from the cytosol. These processes are sometimes driven by the unusual behaviour of the mitochondrial genome from which the RNA is originally transcribed, but in many examples the complex processes that are essential for the production of functional RNA in the organelle, are fascinating and bewildering.
Author(s): Chrzanowska-Lightowlers ZM, Lightowlers RN
Publication type: Review
Publication status: Published
Journal: RNA Biology
Year: 2024
Volume: 21
Issue: 1
Pages: 28-39
Online publication date: 10/10/2024
Acceptance date: 30/09/2024
ISSN (print): 1547-6286
ISSN (electronic): 1555-8584
Publisher: Taylor and Francis Ltd.
URL: https://doi.org/10.1080/15476286.2024.2414157
DOI: 10.1080/15476286.2024.2414157
PubMed id: 39385590
