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Lookup NU author(s): Harry Clifford, Professor Yujiang WangORCiD, Dr Rhys ThomasORCiD, Dr Tiago da Silva Costa, Professor Peter TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.Vagus nerve stimulation (VNS) is an established therapy for drug-resistant epilepsy. However, there is a lack of reliable predictors of VNS response in clinical use. The identification of factors predictive of VNS response is important for patient selection and stratification as well as tailored stimulation programming. We conducted a narrative review of the existing literature on prognostic markers for VNS response using clinical, demographic, biochemical, and modality-specific information such as from electroencephalography (EEG), magnetoencephalography, and magnetic resonance imaging (MRI). No individual marker demonstrated sufficient predictive power for individual patients, although several have been suggested, with some promising initial findings. Combining markers from underresearched modalities such as T1-weighted MRI morphometrics and EEG may provide better strategies for treatment optimization.
Author(s): Clifford HJ, Paranathala MP, Wang Y, Thomas RH, da SilvaCosta T, Duncan JS, Taylor PN
Publication type: Review
Publication status: Published
Journal: Epilepsia
Year: 2024
Pages: epub ahead of print
Online publication date: 16/10/2024
Acceptance date: 04/10/2024
ISSN (print): 0013-9580
ISSN (electronic): 1528-1167
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/epi.18153
DOI: 10.1111/epi.18153
Data Access Statement: Data sharing not applicable to this article as no datasets were generated or analysed during the current study
