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Lookup NU author(s): Peter LukeORCiD, Dr Mohammad Alkhalil, Professor Christopher EggettORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Aortic stenosis (AS) is a complex and progressive condition that can significantly reduce the quality of life and increase the incidence of premature mortality. Transthoracic echocardiography (TTE) is the gold standard imaging modality for the assessment of AS severity. While left ventricular ejection fraction (LVEF) derived from TTE is a very well understood parameter, limitations such as high inter and intra-observer variability, insensitivity to sub-clinical dysfunction, and influence of loading conditions make LVEF a complicated and unreliable parameter. Myocardial deformation imaging has been identified as a promising parameter for identifying subclinical left ventricular dysfunction, however, this parameter is still afterload dependent. Myocardial Work is a promising novel assessment technique that accounts for afterload by combining the use of myocardial deformation imaging and non-invasive blood pressure to provide amore comprehensive assessment of mechanics beyond LVEF. This review evaluates the evidence for various echocardiographic assessment parameters used to quantify left ventricular function including myocardial work in patients with AS.
Author(s): Luke PL, Alkhalil M, Eggett C
Publication type: Article
Publication status: Published
Journal: Echocardiography
Year: 2022
Volume: 39
Issue: 12
Pages: 1470-1480
Print publication date: 08/12/2022
Online publication date: 29/11/2022
Acceptance date: 06/11/2022
Date deposited: 13/11/2024
ISSN (print): 0742-2822
ISSN (electronic): 1540-8175
Publisher: Wiley
URL: https://doi.org/10.1111/echo.15497
DOI: 10.111/echo.15497
PubMed id: 36447299
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