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Lookup NU author(s): Dr Alan Fenton
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024. Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares (OLS) regression were used to explore the associations between the presence and severity of congenital anomalies. Results: The mean total PedsQL™ GCS score for children with a mild congenital anomaly was lower than the respective value for children without a congenital anomaly by 3.7 points (p < 0.05), controlling for socioeconomic variables only; this effect was attenuated when accumulatively adjusting for perinatal characteristics (3.3 points (p < 0.05)) and neonatal morbidities (3.1 (p < 0.05)). The mean total PedsQL™ GCS scores for children who had a severe congenital anomaly were lower by 7.1 points (p < 0.001), 6.6 points (p < 0.001) and 6.0 points (p < 0.001) when accumulatively adjusting for socioeconomic, perinatal and neonatal variables, respectively. Conclusion: This study revealed that the presence and severity of congenital anomalies are significant predictors of HRQoL outcomes in children born very preterm. Impact: Children born very preterm with congenital anomalies experience poorer health-related quality of life (HRQoL) than their very preterm counterparts born without congenital anomalies. Increased severity of these anomalies compounds the negative impacts on HRQoL. Our findings can be used by stakeholders for clinical and planning purposes.
Author(s): Tian X, Andronis L, Maier RF, Varendi H, Seppanen A-V, Siljehav V, Draper ES, Zeitlin J, Petrou S, Seppanen AV, El Rafei R, Bonnet C, Aubert AM, Zeitlin J, Andronis L, Kim SW, Kim SW, Petrou S, Pfeil JM, Thiele N, Mader S, Johnson SJ, Fenton A, Draper ES, Aden U, Rodrigues C, Costa R, Barros H, Pikula T, Montgomery A, Mazela J, Gadzinowski J, Koopman-Esseboom C, Ferrari F, Faldella G, Ancora G, Carnielli V, Croci I, Cuttini M, Wohlers L, Misselwitz B, Zemlin M, Maier RF, Truffert P, Pierrat V, Jarreau PH, Burguet A, Ancel PY, Mannamaa M, Varendi H, Toome L, Pedersen P, Boerch K, Sarrechia I, Ortibus E, Oostra A, Cloet E, Bruneel E, Van Reempts P, Lebeer J
Publication type: Article
Publication status: Published
Journal: Pediatric Research
Year: 2025
Volume: 97
Pages: 1711-1721
Print publication date: 01/04/2025
Online publication date: 07/09/2024
Acceptance date: 25/07/2024
Date deposited: 06/11/2024
ISSN (print): 0031-3998
ISSN (electronic): 1530-0447
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41390-024-03521-9
DOI: 10.1038/s41390-024-03521-9
Data Access Statement: The data that support the findings of this study were used under license for the current study, and so are not publicly available.
PubMed id: 39242941
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