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Lookup NU author(s): Professor Katarina NovakovicORCiD, Tarek Abdelghany
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Many chronic diseases require long-term and frequent medication that the patients can find difficult to manage. Transdermal microneedle (MN) patches are convenient as they empower patients to self-medicate in a pain-free way, while avoiding the first-pass effects associated with oral medications, thus increasing bioavailability. This is particularly pertinent for biologics which are almost completely degraded by enzymes in the gastrointestinal tract. However, conventional MN patches have some serious shortcomings including quick drug release, making them short-acting; as well as limited drug load, due to drug loading being constrained to the MN tips only, which inherently are limited in volume. To circumvent the limitations of current MN technology, we have formulated a composite material that provides Ultra-Long and Tunable Release of Actives (ULTRA) and, accordingly, ULTRA MN patches with increased drug loading and extended release of both small drugs and macromolecular biologics. The model drug used in this study was methylene blue (MB), a hydrophilic drug selected to push the limits of extended drug release and demonstrate the capabilities of the ULTRA MN patch.
Author(s): Novakovic K, Lau WM, Abdelghany T, Wooi KN
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: UK Society for Biomaterials Conference
Year of Conference: 2024
Print publication date: 10/06/2024
Online publication date: 10/06/2024
Acceptance date: 06/05/2024
URL: https://www.uksb.org.uk/uksb2024/
