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Lookup NU author(s): Dr Pasquale RescignoORCiD
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© 2024 Informa UK Limited, trading as Taylor & Francis Group.Introduction: The Meet-URO 18 study is a multicentric study of patients with metastatic renal cell carcinoma receiving nivolumab in the second-line and beyond, categorized as responders (progression-free survival ≥ 12 months) and non-responders (progression-free survival < 3 months). Areas covered: The current study includes extensive immunohistochemical analysis of T-lineage markers (CD3, CD4, CD8, CD8/CD4 ratio), macrophages (CD68), ph-mTOR, CD15 and CD56 expression on tumor cells, and PD-L1 expression, on an increased sample size including 161 tumor samples (113 patients) compared with preliminary presented data. Responders‘ tumor tissue (n = 90; 55.9%) was associated with lower CD4 expression (p = 0.014), higher CD56 expression (p = 0.046) and higher CD8/CD4 ratio (p = 0.030). Expert opinion/commentary: The present work suggests the regulatory role of a subpopulation of T cells on antitumor response and identifies CD56 as a putative biomarker of immunotherapy efficacy.
Author(s): Catalano F, Brunelli M, Signori A, Rescigno P, Buti S, Galli L, Spada M, Masini C, Galuppini F, Vellone VG, Gaggero G, Maruzzo M, Merler S, Vignani F, Cavo A, Bimbatti D, Milella M, Dei Tos AP, Sbaraglia M, Murianni V, Damassi A, Cremante M, Maffezzoli M, Llaja Obispo MA, Banna GL, Fornarini G, Rebuzzi SE
Publication type: Article
Publication status: Published
Journal: Future Oncology
Year: 2024
Volume: 20
Issue: 21
Pages: 1495-1503
Online publication date: 12/06/2024
Acceptance date: 05/04/2024
ISSN (print): 1479-6694
ISSN (electronic): 1744-8301
Publisher: Taylor and Francis Ltd.
URL: https://doi.org/10.2217/fon-2023-1068
DOI: 10.2217/fon-2023-1068
PubMed id: 38682738
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