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Lookup NU author(s): Dr Pasquale RescignoORCiD
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© The Author(s) 2023. Introduction: Apalutamide is an oral selective androgen receptor inhibitor, approved by the FDA for the treatment of patients with non-metastatic, castration-resistant prostate cancer (M0 CRPC) at high risk of developing metastases and for patients with metastatic castration-sensitive prostate (mHSPC) in association with androgen deprivation therapy (ADT). In the registration studies, skin reactions were reported among the most common side effects and as an adverse event of special interest. Case Report: Apalutamide-induced rash includes a wide spectrum of different types of skin reactions, but few cases reports and case series have described this adverse event. Here, we report an M0 CRPC patient who experienced a rare skin adverse event, a lichenoid reaction. Management & Outcome: After 4 months of therapy with apalutamide, the patient reported dorsal pricking and dry skin. Lichenoid reaction was confirmed histologically and its correlation to the drug was demonstrated after pursuing a multidisciplinary approach. Discussion: To our knowledge, this is one of the first cases of Apalutamide-related lichenoid reaction and this clinical case showed the relevance of a multidisciplinary management when assessing drug-related adverse events. A broader knowledge of the spectrum of drug-related reactions would allow for a better diagnosis and therapy management by both physicians and patients.
Author(s): Cremante M, Puglisi S, Gandini A, Guadagno A, Catalano F, Damassi A, Murianni V, Llaja Obispo MA, Banna GL, Buti S, Rebuzzi SE, Rescigno P, Fornarini G
Publication type: Article
Publication status: Published
Journal: Journal of Oncology Pharmacy Practice
Year: 2023
Volume: 29
Issue: 7
Pages: 1748-1753
Print publication date: 01/10/2023
Online publication date: 06/06/2023
Acceptance date: 02/04/2018
ISSN (print): 1078-1552
ISSN (electronic): 1477-092X
Publisher: SAGE Publications Ltd
URL: https://doi.org/10.1177/10781552231180598
DOI: 10.1177/10781552231180598
PubMed id: 37282554
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