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The role of the caregiver in older patients with advanced prostate cancer: results from the ADHERE Prospective Study of the Meet-URO network

Lookup NU author(s): Dr Pasquale RescignoORCiD

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Abstract

© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Purpose: To assess caregivers’ characteristics and influence of the presence or absence of the caregiver on clinical outcomes of older (≥70 years) metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone (ABI) or enzalutamide (ENZ). Methods: Patients from the Meet-URO 5 ADHERE study were assessed with a 5-item caregiver evaluation questionnaire focusing on the presence, age, degree of kinship, working status and qualification of the caregiver. We investigated the association between the presence of a caregiver and the clinical characteristics and outcomes of enrolled patients. Results: No differences were found in the main clinical characteristics between patients with or without a caregiver, except for a lower median G8 score (p = 0.0453) in the caregiver group. A longer radiographic PFS (rPFS) was observed in the group without a caregiver, with a trend towards more prolonged overall survival (OS) in the same group. Conclusion: Our work suggests a detrimental effect of caregivers in managing older mCRPC patients treated with ABI or ENZ, especially those identified as frail by the geriatric G8 screening score. Further work is needed to identify and address patients’ vulnerability areas, which could have a detrimental effect on prognosis.

Publication metadata

Author(s): Giunta EF, De Padova S, Anpalakhan S, De Giorgi U, Maruzzo M, Rebuzzi SE, Cinausero M, Fratino L, Lipari H, Gamba T, Bimbatti D, Dri A, Ermacora P, Vignani F, Basso U, Buti S, Gandini A, Cremante M, Fornarini G, Rescigno P, Banna GL

Publication type: Article

Publication status: Published

Journal: Supportive Care in Cancer

Year: 2023

Volume: 31

Issue: 7

Online publication date: 26/06/2023

Acceptance date: 27/04/2023

ISSN (print): 0941-4355

ISSN (electronic): 1433-7339

Publisher: Springer Science and Business Media Deutschland GmbH

URL: https://doi.org/10.1007/s00520-023-07867-4

DOI: 10.1007/s00520-023-07867-4

PubMed id: 37358628

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