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Lookup NU author(s): Dr Pasquale RescignoORCiD
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© 2023 Future Medicine Ltd. Plain language summary Immunotherapy is an effective treatment strategy across different cancer types and could be a valid treatment strategy in patients with multiple malignant tumors. In this scenario, in fact, the main challenge is to choose a systemic treatment which could be active on both tumors with an acceptable toxicity profile. The authors report the clinical case of a patient with metastatic renal cell carcinoma and a disfiguring cutaneous cancer of the zygomatic region who experienced a durable response of the renal tumor and almost a complete clinical response of the cutaneous cancer. Immune checkpoint inhibitors have significantly improved the therapeutic scenario of many different advanced malignancies and could be an effective treatment strategy in synchronous or metachronous tumors. The authors describe the clinical case of a patient who experienced a long-lasting response of his metastatic renal cell carcinoma and an optimal response of his locally advanced cutaneous squamous cell carcinoma to immunotherapy. The systemic treatment was chosen based on a literature review of several clinical reports, since there was no prospective study on anti-PD-1 blockade activity in cutaneous squamous cell carcinoma when the patient started the treatment. This clinical case supports the growing evidence for immunotherapy as a valid treatment option across different types of advanced tumors.
Author(s): Murianni V, Cerbone L, Rescigno P, Catalano F, Damassi A, Cremante M, Gandini A, Puglisi S, Pesola G, Banna GL, Buti S, Signori A, Fornarini G, Rebuzzi SE
Publication type: Article
Publication status: Published
Journal: Immunotherapy
Year: 2023
Volume: 14
Issue: 18
Pages: 1419-1427
Online publication date: 04/01/2023
Acceptance date: 30/11/2022
ISSN (print): 1750-743X
ISSN (electronic): 1750-7448
Publisher: Taylor & Francis
URL: https://doi.org/10.2217/imt-2022-0150
DOI: 10.2217/imt-2022-0150
PubMed id: 36597723
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