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The Geriatric G8 Score Is Associated with Survival Outcomes in Older Patients with Advanced Prostate Cancer in the ADHERE Prospective Study of the Meet-URO Network

Lookup NU author(s): Dr Pasquale RescignoORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2022 by the authors.Introduction: Androgen receptor pathway inhibitors (ARPIs) have been increasingly offered to older patients with prostate cancer (PC). However, prognostic factors relevant to their outcome with ARPIs are still little investigated. Methods and Materials: The Meet-URO network ADHERE was a prospective multicentre observational cohort study evaluating and monitoring adherence to ARPIs metastatic castrate-resistant PC (mCRPC) patients aged ≥70. Cox regression univariable and multivariable analyses for radiographic progression-free (rPFS) and overall survival (OS) were performed. Unsupervised median values and literature-based thresholds where available were used as cut-offs for quantitative variables. Results: Overall, 234 patients were enrolled with a median age of 78 years (73–82); 86 were treated with abiraterone (ABI) and 148 with enzalutamide (ENZ). With a median follow-up of 15.4 months (mo.), the median rPFS was 26.0 mo. (95% CI, 22.8–29.3) and OS 48.8 mo. (95% CI, 36.8–60.8). At the MVA, independent prognostic factors for both worse rPFS and OS were Geriatric G8 assessment ≤ 14 (p < 0.001 and p = 0.004) and PSA decline ≥50% (p < 0.001 for both); time to castration resistance ≥ 31 mo. and setting of treatment (i.e., post-ABI/ENZ) for rPFS only (p < 0.001 and p = 0.01, respectively); age ≥78 years for OS only (p = 0.008). Conclusions: Baseline G8 screening is recommended for mCRPC patients aged ≥70 to optimise ARPIs in vulnerable individuals, including early introduction of palliative care.

Publication metadata

Author(s): Banna GL, Basso U, Giunta EF, Fratino L, Rebuzzi SE, Buti S, Maruzzo M, De Giorgi U, Murianni V, Cinausero M, Lipari H, Gamba T, Caffo O, Bimbatti D, Dri A, Mosca A, Ermacora P, Vignani F, Msaki A, Bonifacio B, Lombardo V, Conteduca V, Fornarini G, Rescigno P

Publication type: Article

Publication status: Published

Journal: Current Oncology

Year: 2022

Volume: 29

Issue: 10

Pages: 7745-7753

Print publication date: 01/10/2022

Online publication date: 14/10/2022

Acceptance date: 11/10/2022

Date deposited: 08/11/2024

ISSN (print): 1198-0052

ISSN (electronic): 1718-7729

Publisher: MDPI

URL: https://doi.org/10.3390/curroncol29100612

DOI: 10.3390/curroncol29100612

Data Access Statement: The datasets generated and analysed during the current study are not publicly available as they are part of the confidential medical record but are available from the corresponding author on reasonable request.

PubMed id: 36290889

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