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Lookup NU author(s): Amar Rajgor, Dr Josh Cowley, Dr Colin GillespieORCiD, Dr Chang Lee, James O'HaraORCiD, David Hamilton
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) Limited. Background: Our centre has favoured primary surgery over chemoradiotherapy(CRT) for specific advanced laryngeal cancer patients (e.g. large volume tumours, airway compromise, significant dysphagia, T4 disease). This study reports the survival outcomes for a modern, high-volume head and neck centre favouring surgical management to determine whether this approach improves survival. Methods: Retrospective analysis of patient data over a 7-year period from a tertiary cancer centre. Results: 121 patients were identified with T3(n=76) or T4 (n=45) laryngeal cancer (mean follow-up 2.9 years). In the cohort treated with curative intent(n=104;86.0%), the 2-year and 5-year estimated disease-specific survival (DSS) was 77.9% and 64.1%. CRT had the highest 2-year DSS (92.5%), followed by surgery with adjuvant therapy (81.8%), radiotherapy alone (75%), and surgery alone (72.4%). Conclusion: For a centre favouring primary surgery for certain advanced laryngeal cancers, the DSS appears no higher than published literature. To enhance survival, future research should focus on precision medicine to define treatment pathways in this disease.
Author(s): Rajgor AD, Cowley J, Gillespie C, Lee CW, O'Hara J, Iqbal MS, Hamilton DW
Publication type: Article
Publication status: Published
Journal: Journal of Laryngology and Otology
Year: 2024
Pages: Epub ahead of print
Online publication date: 21/10/2024
Acceptance date: 02/04/2018
Date deposited: 12/11/2024
ISSN (print): 0022-2151
ISSN (electronic): 1748-5460
Publisher: Cambridge University Press
URL: https://doi.org/10.1017/S0022215124001105
DOI: 10.1017/S0022215124001105
PubMed id: 39429115
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