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Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication

Lookup NU author(s): Dr Emma BriggsORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

The genomes of all organisms are read throughout their growth and development, generating new copies during cell division and encoding the cellular activities dictated by the genome's content. However, genomes are not invariant information stores but are purposefully altered in minor and major ways, adapting cellular behaviour and driving evolution. Kinetoplastids are eukaryotic microbes that display a wide range of such read-write genome activities, in many cases affecting critical aspects of their biology, such as host adaptation. Here we discuss the range of read-write genome changes found in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishmania, focusing on recent work that suggests such adaptive genome variation is linked to novel strategies the parasites use to replicate their unconventional genomes.

Publication metadata

Author(s): Damasceno JD, Marques CA, Black J, Briggs E, McCulloch R

Publication type: Article

Publication status: Published

Journal: Trends in Genetics

Year: 2021

Volume: 37

Issue: 1

Pages: 21-34

Print publication date: 01/01/2021

Online publication date: 28/09/2020

Acceptance date: 01/09/2020

Date deposited: 20/02/2025

ISSN (print): 0168-9525

ISSN (electronic): 1362-4555

Publisher: Cell Press

URL: https://doi.org/10.1016/j.tig.2020.09.002

DOI: 10.1016/j.tig.2020.09.002

PubMed id: 32993968

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