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An Integrative Approach to Decipher the Chemical Antagonism between the Competing Endophytes Paraconiothyrium variabile and Bacillus subtilis

Lookup NU author(s): Dr Katherine DuncanORCiD

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Abstract

© 2017 The American Chemical Society and American Society of Pharmacognosy. An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.

Publication metadata

Author(s): Vallet M, Vanbellingen QP, Fu T, Le Caer J-P, Della-Negra S, Touboul D, Duncan KR, Nay B, Brunelle A, Prado S

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2017

Volume: 80

Issue: 11

Pages: 2863-2873

Print publication date: 22/11/2017

Online publication date: 15/11/2017

Acceptance date: 02/04/2016

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acs.jnatprod.6b01185

DOI: 10.1021/acs.jnatprod.6b01185

PubMed id: 29139291

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