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Lookup NU author(s): Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. BACKGROUND: Parkinson's disease and Huntington's disease are both neurodegenerative conditions involving the basal ganglia area of the brain. Both conditions can cause symptoms that affect movement. Cognitive decline or dementia can also occur in both. Resting state EEG (rsEEG) rhythms reflect neurophysiological mechanisms and operational functions related to the fluctuation of brain arousal and quiet vigilance in humans. The hypothesis was that rsEEG sources may be more abnormal in Huntington's disease patients in symptomatic stage (S-HD) than patients with dementia due to Parkinson's disease. METHOD: Clinical and rsEEG datasets in 16 PDD, 18 S-HD, and 25 matched cognitively unimpaired (Nold) participants - matched as demography, education, and gender - were taken from an international archive. The eLORETA freeware was used to estimate cortical rsEEG sources at delta, theta, alpha1, alpha2, alpha3, beta1, beta2, and gamma frequency bands. RESULT: Results showed lower amplitude of the posterior alpha activities and higher amplitude of widespread low frequencies bands (i.e., delta and theta) in the PDD and S-HD groups than in the Healthy group. As compared to the PDD group, the S-HD showed greater reductions in the rsEEG alpha 2 rhythms in the frontal and temporal regions (see Figure 1). CONCLUSION: These results suggest that cortical sources of rsEEG rhythms might reflect different abnormalities of the core neurophysiological mechanisms underlying brain arousal in quiet wakefulness and low vigilance in PDD, and S-HD patients. The mentioned rsEEG markers might be clinically useful in the disease staging, monitoring over time, and drug discovery.
Author(s): Noce G, Percio CD, Lizio R, Lopez S, Jakhar D, Guntekin B, Yener G, Taylor J-P, De Tommaso M, Delussi M, Babiloni C
Publication type: Article
Publication status: Published
Journal: Alzheimer's & Dementia
Year: 2024
Volume: 20
Issue: S1
Print publication date: 01/12/2024
Online publication date: 03/01/2025
Acceptance date: 02/04/2018
Date deposited: 21/01/2025
ISSN (print): 1552-5260
ISSN (electronic): 1552-5279
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/alz.090670
DOI: 10.1002/alz.090670
PubMed id: 39750766
Notes: Supplement: Basic Science and Pathogenesis
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