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The Natural Products Atlas 3.0: Extending the database of microbially derived natural products

Lookup NU author(s): Dr Katherine DuncanORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

© 2025 The Author(s) 2024. The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthetic and chemical ontology classifications, grouping by compound classes and cross-links to a suite of other natural product-related data resources. The database is supported by a web server that includes functionality to browse the collection, search the database using both chemical structures and text/numerical terms and visualize the chemical diversity it contains using interactive dashboards. In the current database release, we have curated 1347 papers, increasing the number of compounds to 36 545. In addition, we have initiated a large-scale effort to incorporate data from papers reporting structural reassignments and revisions to previously published structures. This effort led to the incorporation of 590 corrections to existing entries, significantly improving the accuracy of the dataset. The Natural Products Atlas may be accessed at www.npatlas.org.


Publication metadata

Author(s): Poynton EF, Van Santen JA, Pin M, Contreras MM, McMann E, Parra J, Showalter B, Zaroubi L, Duncan KR, Linington RG

Publication type: Article

Publication status: Published

Journal: Nucleic Acids Research

Year: 2025

Volume: 53

Issue: D1

Pages: D691-D699

Print publication date: 06/01/2025

Online publication date: 26/11/2024

Acceptance date: 24/10/2024

Date deposited: 22/01/2025

ISSN (print): 0305-1048

ISSN (electronic): 1362-4962

Publisher: Oxford University Press

URL: https://doi.org/10.1093/nar/gkae1093

DOI: 10.1093/nar/gkae1093

Data Access Statement: The data underlying this article are available in the Natural Products Atlas at www.npatlas.org. Documentation for the API is available at https://www.npatlas.org/api/v1/docs. Previous releases of the Natural Products Atlas database are available in Zenodo at https://dx.doi.org/10.5281/zenodo.3530792.

PubMed id: 39588755


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Funding

Funder referenceFunder name
Department for Environment, Food and Rural Affairs, UK Government (DEFRA)
HORIZON EUROPE Marie Skłodowska-Curie Actions [101072485]
Natural Sciences and Engineering Research Council of Canada
UK Research and Innovation [EP/X03142X/1]

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