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Microbe Profile: Pseudonocardia: antibiotics for every niche

Lookup NU author(s): Dr Katherine DuncanORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2024 The Authors. Pseudonocardia species comprise a genus of filamentous, sporulating bacteria belonging to the phylum Actinomycetota, formerly Actinobacteria. They are found in marine and freshwater sediments and soils and associated with marine animals, insects, and plants. To date, they have mostly been studied because of their mutually beneficial symbiosis with fungus-growing ants in the tribe Attini. They have also attracted interest due to their biosynthetic capabilities, including the production of variably glycosylated polyenes and other novel antifungal compounds, and for their capacity to grow on a variety of hydrocarbons. The majority of clinically used antibiotics are derived from the specialised metabolites of filamentous actinomycete bacteria and most of these come from the genus Streptomyces. However, in the quest for novel chemistry there is increasing interest in studying other filamentous actinomycete genera, including Pseudonocardia. Here we outline the biological properties, genome size and structure and key features of the genus Pseudonocardia, namely their specialised metabolites and ecological roles.


Publication metadata

Author(s): Whatmough B, Holmes NA, Wilkinson B, Hutchings MI, Parra J, Duncan KR

Publication type: Article

Publication status: Published

Journal: Microbiology

Year: 2024

Volume: 170

Issue: 9

Online publication date: 19/09/2024

Acceptance date: 27/08/2024

Date deposited: 22/01/2025

ISSN (print): 1350-0872

ISSN (electronic): 1465-2080

Publisher: Microbiology Society

URL: https://doi.org/10.1099/mic.0.001501

DOI: 10.1099/mic.0.001501

PubMed id: 39297772


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Funding

Funder referenceFunder name
Natural Environment Research Council (responsive mode grants NE/M015033/1 and NE/M014657/1)
Natural Environment Research Council (responsive mode grants NE/M015033/1, NE/M014657/1, E/J01074X/1)
Programa de Innovación y Capital Humano para la Competitividad (PINN) of the Ministerio de Ciencia Tecnología y Telecomunicaciones, Costa Rica (MICITT) (grant 2-1-4-17-1–037)
The Medical Research Council (Milstein award GG0801721)
the Natural Environment Research Council and the ARIES Doctoral Training Partnership (grant number E/S007334/1)

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