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Lookup NU author(s): Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Authors. Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8–10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex. An international database provided clinical-demographic-rsEEG datasets for cognitively unimpaired older (Healthy; N = 49; 24 females), PDD (N = 39; 13 females), and DLB (N = 38; 15 females) participants. Each group was stratified into matched female and male subgroups. The rsEEG rhythms were investigated across the individual rsEEG delta, theta, and alpha frequency bands based on the individual alpha frequency peak. The eLORETA freeware was used to estimate cortical rsEEG sources. In the Healthy group, widespread rsEEG alpha source activities were greater in the females than in the males. In the PDD group, widespread rsEEG delta source activities were lower and widespread rsEEG alpha source activities were greater in the females than in the males. In the DLB group, central-parietal rsEEG delta source activities were lower, and posterior rsEEG alpha source activities were greater in the females than in the males. These results suggest sex-dependent hormonal modulation of neuroprotective-compensatory neurophysiological mechanisms in PDD and DLB patients underlying the generation of rsEEG delta and alpha rhythms, which should be considered in the treatment of vigilance dysregulation in those patients.
Author(s): Del Percio C, Lizio R, Lopez S, Noce G, Jakhar D, Carpi M, Bolukbas B, Soricelli A, Salvatore M, Guntekin B, Yener G, Massa F, Arnaldi D, Fama F, Pardini M, Ferri R, Salerni M, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP, Hanoglu L, Helvaci Yilmaz N, Kiyi I, Ozbek-Isbitiren Y, Frisoni GB, Cuoco S, Barone P, D'Anselmo A, Bonanni L, Biundo R, D'Antonio F, Bruno G, Giubilei F, De Pandis F, Rotondo R, Antonini A, Babiloni C
Publication type: Article
Publication status: Published
Journal: Neurobiology of Disease
Year: 2025
Volume: 206
Print publication date: 01/03/2025
Online publication date: 22/01/2025
Acceptance date: 16/01/2025
Date deposited: 04/02/2025
ISSN (print): 0969-9961
ISSN (electronic): 1095-953X
Publisher: Academic Press Inc.
URL: https://doi.org/10.1016/j.nbd.2025.106807
DOI: 10.1016/j.nbd.2025.106807
Data Access Statement: Data will be made available on request.
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