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Lookup NU author(s): Dana Hutton
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© 2025Ganglioglioma is a rare primary brain tumour that most frequently occurs in children and young adults. They are generally low-grade and have a favourable prognosis, but there is limited literature to guide the optimal management. The aim of this study was to investigate the clinical outcomes of adults with intracranial ganglioglioma, and to determine the frequency and duration of radiological follow-up. Thirteen adult patients with CNS WHO grade 1 and 2 ganglioglioma were identified retrospectively from case records at a tertiary neurosurgical centre between 2010 and 2022. Patient characteristics, magnetic resonance imaging (MRI) features, and clinical outcomes were obtained. Surgery was classified as gross total (GTR) or subtotal (STR) resection. 84.6 % (n = 11) of patients had temporal lobe tumours, with most (69.2 %) presenting with seizures, at a median age of 29.0 years. GTR and STR were achieved in nine and five patients, respectively. No patients received adjuvant radiotherapy. During the median follow-up period of 8.9 years there was no radiological recurrence after GTR, and only one recurrence after STR at 65 months that did not require treatment. There was no patient mortality. Two patients continued to have seizures at last clinical follow-up. Low grade adult intracranial ganglioglioma has an excellent prognosis, with a recurrence rate below 10 % in this series. Long-term surveillance is not necessarily required if GTR has been achieved and patients can be considered for discharge after annual MRI for 5 years. In patients where only STR is achieved, annual MRI is required although the progression/recurrence rate remains low and asymptomatic.
Author(s): Hutton DL, Kulkarni J, Syed K, Scott I, Cearns MD, Mills SJ, Jenkinson MD
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Neuroscience
Year: 2025
Volume: 134
Print publication date: 01/04/2025
Online publication date: 29/01/2025
Acceptance date: 23/01/2025
ISSN (print): 0967-5868
ISSN (electronic): 1532-2653
Publisher: Elsevier
URL: https://doi.org/10.1016/j.jocn.2025.111088
DOI: 10.1016/j.jocn.2025.111088
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