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Lookup NU author(s): Dr Matt BawnORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Authors. Aeromonas spp. are associated with a number of infectious syndromes in humans including gastroenteritis and dysentery. Our understanding of the genetic diversity, population structure, virulence determinants and antimicrobial resistance of the genus has been limited by a lack of sequenced genomes linked to metadata. We performed a comprehensive analysis of the whole genome sequences of 447 Aeromonas isolates from children in Karachi, Pakistan, with moderate-to-severe diarrhoea (MSD) and from matched controls without diarrhoea that were collected as part of the Global Enteric Multicenter Study (GEMS). Human-associated Aeromonas isolates exhibited high species diversity and extensive antimicrobial and virulence gene content. Aeromonas caviae, A. dhankensis, A. veronii and A. enteropelogenes were all significantly associated with MSD in at least one cohort group. The maf2 and lafT genes that encode components of polar and lateral flagella, respectively, exhibited a weak association with isolates originating from cases of gastroenteritis.
Author(s): Klemm EJ, Nisar MI, Bawn M, Nasrin D, Qamar FN, Page A, Qadri F, Shakoor S, Zaidi AKM, Levine MM, Dougan G, Kingsley RA
Publication type: Article
Publication status: Published
Journal: Microbial Genomics
Year: 2024
Volume: 10
Issue: 3
Online publication date: 07/03/2024
Acceptance date: 15/02/2024
Date deposited: 10/02/2025
ISSN (electronic): 2057-5858
Publisher: Microbiology Society
URL: https://doi.org/10.1099/mgen.0.001211
DOI: 10.1099/mgen.0.001211
Data Access Statement: The authors confirm all supporting data, code and protocols have been provided within the article or through supplementary data files. Sequence data are available in the European Nucleotide Archive (http://www.ebi.ac.uk/ena) under project accession numbers PRJEB15489 and PRJEB1611.
PubMed id: 38451244
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