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Lookup NU author(s): Dr Luke BashfordORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 Society for Neuroscience. All rights reserved.Intracortical microstimulation (ICMS) in human primary somatosensory cortex (S1) has been used to successfully evoke naturalistic sensations. However, the neurophysiological mechanisms underlying the evoked sensations remain unknown. To understand how specific stimulation parameters elicit certain sensations we must first understand the representation of those sensations in the brain. In this study we record from intracortical microelectrode arrays implanted in S1, premotor cortex, and posterior parietal cortex of a male human participant performing a somatosensory imagery task. The sensations imagined were those previously elicited by ICMS of S1, in the same array of the same participant. In both spike and local field potential recordings, features of the neural signal can be used to classify different imagined sensations. These features are shown to be stable over time. The sensorimotor cortices only encode the imagined sensation during the imagery task, while posterior parietal cortex encodes the sensations starting with cue presentation. These findings demonstrate that different aspects of the sensory experience can be individually decoded from intracortically recorded human neural signals across the cortical sensory network. Activity underlying these unique sensory representations may inform the stimulation parameters for precisely eliciting specific sensations via ICMS in future work.
Author(s): Bashford L, Rosenthal I, Kellis S, Pejsa K, Kramer D, Lee B, Liu C, Andersen RA
Publication type: Article
Publication status: Published
Journal: Journal of Neuroscience
Year: 2021
Volume: 41
Issue: 10
Pages: 2180-2185
Print publication date: 10/03/2021
Online publication date: 22/01/2021
Acceptance date: 06/01/2021
Date deposited: 05/03/2025
ISSN (print): 0270-6474
ISSN (electronic): 1529-2401
Publisher: Society for Neuroscience
URL: https://doi.org/10.1523/JNEUROSCI.2460-20.2021
DOI: 10.1523/JNEUROSCI.2460-20.2021
PubMed id: 33483431
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