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Histamine in the neocortex: Towards integrating multiscale effectors

Lookup NU author(s): Amrita BenoyORCiD, Dr Srikanth RamaswamyORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The Author(s). European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. Histamine is a modulatory neurotransmitter, which has received relatively less attention in the central nervous system than other neurotransmitters. The functional role of histamine in the neocortex, the brain region that controls higher-order cognitive functions such as attention, learning and memory, remains largely unknown. This article focuses on the emerging roles and mechanisms of histamine release in the neocortex. We describe gaps in current knowledge and propose the application of interdisciplinary tools to dissect the detailed multiscale functional logic of histaminergic action in the neocortex ranging from sub-cellular, cellular, dendritic and synaptic levels to microcircuits and mesoscale effects.

Publication metadata

Author(s): Benoy A, Ramaswamy S

Publication type: Article

Publication status: Published

Journal: European Journal of Neuroscience

Year: 2024

Volume: 60

Issue: 4

Pages: 4597-4623

Print publication date: 01/08/2024

Online publication date: 20/07/2024

Acceptance date: 05/06/2024

Date deposited: 05/03/2025

ISSN (print): 0953-816X

ISSN (electronic): 1460-9568

Publisher: John Wiley and Sons Inc.

URL: https://doi/org/10.1111/ejn.16447

DOI: 10.1111/ejn.16447

Data Access Statement: Data sharing does not apply to this article as no new data were created or analysed in this study.

PubMed id: 39032115

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