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Lookup NU author(s): Professor John IsaacsORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2025 The Authors. In light of the introduction of new Janus kinase inhibitors (JAKi), new indications for JAKi and recent safety considerations that have arisen since the preceding consensus statement on JAKi therapy, a multidisciplinary taskforce was assembled, encompassing patients, health care professionals, and clinicians with expertise in JAKi therapy across specialties. This taskforce, informed by two comprehensive systematic literature reviews, undertook the objective to update the previous expert consensus for using JAKi developed in 2019. The taskforce deliberated on overarching principles, indications, dosage and comedication strategies, warnings and contraindications, screening protocols, monitoring recommendations, and adverse effect profiles. The methodology was based on the European Alliance of Associations for Rheumatology standard operating procedures, with voting on these important elements. Furthermore, an updated research agenda was proposed. The task force did not address when a JAKi should be prescribed but rather considerations once this decision has been made. This update aimed to equip clinicians with the necessary knowledge and guidance for the efficient and safe administration of this expanding and significant class of drugs.
Author(s): Nash P, Kerschbaumer A, Konzett V, Aletaha D, Dorner T, Fleischmann R, McInnes I, Primdahl J, Sattar N, Tanaka Y, Trauner M, Winthrop K, de Wit M, Askling J, Baraliakos X, Boehncke W-H, Emery P, Gossec L, Isaacs JD, Krauth M, Lee EB, Maksymowych W, Pope J, Scholte-Voshaar M, Schreiber K, Schreiber S, Stamm T, Taylor PC, Takeuchi T, Tam L-S, Van den Bosch F, Westhovens R, Zeitlinger M, Smolen JS
Publication type: Article
Publication status: Published
Journal: Annals of the Rheumatic Diseases
Year: 2025
Pages: Epub ahead of print
Online publication date: 03/03/2025
Acceptance date: 16/12/2024
Date deposited: 17/03/2025
ISSN (print): 0003-4967
ISSN (electronic): 1468-2060
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.ard.2025.01.032
DOI: 10.1016/j.ard.2025.01.032
Data Access Statement: All data obtained during the process have been disclosed in this article, and there is nothing else to share.
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