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The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment

Lookup NU author(s): Professor Neil PerkinsORCiD

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Abstract

The kinase IKKα phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of Science Signaling, Alonso-Marañón et al. demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the ATM/IKKα complex to sites of DNA damage, thus enhancing DNA repair and chemotherapy resistance.

Publication metadata

Author(s): Perkins ND

Publication type: Review

Publication status: Published

Journal: Science Signaling

Year: 2025

Volume: 18

Issue: 877

Print publication date: 11/03/2025

Acceptance date: 14/02/2025

ISSN (print): 1945-0877

ISSN (electronic): 1937-9145

URL: https://doi.org/10.1126/scisignal.adv1265

DOI: 10.1126/scisignal.adv1265

PubMed id: 40067906

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