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Robust inference for the unification of confidence intervals in meta-analysis

Lookup NU author(s): Professor Hongsheng DaiORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Traditional meta-analysis assumes that the effect sizes estimated in individual studies follow a Gaussian distribution. However, this distributional assumption is not always satisfied in practice, leading to potentially biased results. In the situation when the number of studies, denoted as $K$, is large, the cumulative Gaussian approximation errors from each study could make the final estimation unreliable. In the situation when $K$ is small, it is not realistic to assume the random-effect follows Gaussian distribution. In this paper, we present a novel empirical likelihood method for combining confidence intervals under the meta-analysis framework. This method is free of the Gaussian assumption in effect size estimates from individual studies and from the random-effects. We establish the large-sample properties of the non-parametric estimator, and introduce a criterion governing the relationship between the number of studies, $K$, and the sample size of each study, $n_i$. Our methodology supersedes conventional meta-analysis techniques in both theoretical robustness and computational efficiency. We assess the performance of our proposed methods using simulation studies, and apply our proposed methods to two examples.


Publication metadata

Author(s): Liang W, Huang H, Dai H, Wei Y

Publication type: Article

Publication status: Published

Journal: Journal of Nonparametric Statistics

Year: 2025

Pages: epub ahead of print

Online publication date: 15/04/2025

Acceptance date: 04/04/2025

Date deposited: 09/04/2025

ISSN (print): 1048-5252

ISSN (electronic): 1029-0311

Publisher: Taylor & Francis

URL: https://doi.org/10.1080/10485252.2025.2492254

DOI: 10.1080/10485252.2025.2492254


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Funding

Funder referenceFunder name
EP/X027872/1
EP/X525789/1
EPSRC
Fundamental Research Funds for the Central Universities
MC/W021358/1
UKRI OCEAN grant, EP/Y014650/1
UKRI MRC Fellowship (MC/W021358/1)

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