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Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies

Lookup NU author(s): Dr Paul DonaghyORCiD, Dr Jahfer HasoonORCiD, Dr Calum HamiltonORCiD, Dr Joanna Ciafone, Dr Rory Durcan, Nicola Barnett, Kirsty OlsenORCiD, Dr Sarah Lawley, Dr Michael FirbankORCiD, Dr Louise Allan, Professor John O'Brien, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Background: Little is known about the prognostic value of plasma biomarkers in mild cognitive impairment with Lewy bodies (MCI-LB). Objectives: To investigate the association of four plasma biomarkers with disease progression in MCI. Methods: Plasma amyloid-beta (Aβ)42/40, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau 181 (pTau181) were measured at baseline in a longitudinal MCI cohort (n = 131). Results: Baseline plasma NfL was associated with increased risk of dementia/death in the entire cohort. In MCI-LB, baseline plasma NfL, GFAP, and pTau181 were associated with increased risk of dementia/death and increased cognitive decline measured by the Addenbrooke's Cognitive Examination-Revised. Conclusions: pTau181, GFAP, and NfL are associated with more rapid disease progression in MCI-LB and, with further validation, could be useful to support prognosis and stratification for clinical practice and treatment trials. Further work, including clinicopathological studies, is needed to understand the biological correlates of these markers in MCI-LB. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.


Publication metadata

Author(s): Donaghy PC, Hasoon J, Hamilton CA, Ciafone J, Durcan R, Barnett N, Olsen K, Lawley S, Greenfinch G, Firbank M, Heslegrave A, Zetterberg H, Allan L, O'Brien JT, Taylor J-P, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2025

Pages: Epub ahead of print

Online publication date: 29/03/2025

Acceptance date: 12/03/2025

Date deposited: 14/04/2025

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/mds.30181

DOI: 10.1002/mds.30181

Data Access Statement: Data and blood samples are available through Dementias Platform UK (www.dementiasplatform.uk).


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Funding

Funder referenceFunder name
Alzheimer's Society
ARUK-PG3026-13
Alzheimer's Research UK
AS-CTP-23-003
GE Healthcare
MR/W000229/1
Medical Research Council
NIHR Cambridge Biomedical Research Centre
NIHR Clinical Research Network North East and North Cumbria
NIHR Exeter Biomedical Research Centre
NIHR Newcastle Biomedical Research Centre
University College London Hospitals Biomedical Research Centre
UK Dementia Research Institute
UKDRI-1003
Weston Family Foundation

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