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Lookup NU author(s): Dr Paul DonaghyORCiD, Dr Jahfer HasoonORCiD, Dr Calum HamiltonORCiD, Dr Joanna Ciafone, Dr Rory Durcan, Nicola Barnett, Kirsty OlsenORCiD, Dr Sarah Lawley, Dr Michael FirbankORCiD, Dr Louise Allan, Professor John O'Brien, Professor John-Paul TaylorORCiD, Professor Alan ThomasORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Background: Little is known about the prognostic value of plasma biomarkers in mild cognitive impairment with Lewy bodies (MCI-LB). Objectives: To investigate the association of four plasma biomarkers with disease progression in MCI. Methods: Plasma amyloid-beta (Aβ)42/40, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau 181 (pTau181) were measured at baseline in a longitudinal MCI cohort (n = 131). Results: Baseline plasma NfL was associated with increased risk of dementia/death in the entire cohort. In MCI-LB, baseline plasma NfL, GFAP, and pTau181 were associated with increased risk of dementia/death and increased cognitive decline measured by the Addenbrooke's Cognitive Examination-Revised. Conclusions: pTau181, GFAP, and NfL are associated with more rapid disease progression in MCI-LB and, with further validation, could be useful to support prognosis and stratification for clinical practice and treatment trials. Further work, including clinicopathological studies, is needed to understand the biological correlates of these markers in MCI-LB. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Author(s): Donaghy PC, Hasoon J, Hamilton CA, Ciafone J, Durcan R, Barnett N, Olsen K, Lawley S, Greenfinch G, Firbank M, Heslegrave A, Zetterberg H, Allan L, O'Brien JT, Taylor J-P, Thomas AJ
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Year: 2025
Pages: Epub ahead of print
Online publication date: 29/03/2025
Acceptance date: 12/03/2025
Date deposited: 14/04/2025
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/mds.30181
DOI: 10.1002/mds.30181
Data Access Statement: Data and blood samples are available through Dementias Platform UK (www.dementiasplatform.uk).
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