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Addressing cardiovascular risks with a goal to prevent cardiovascular complications in patients undergoing antihormonal therapy for prostate cancer

Lookup NU author(s): Dr Chris PlummerORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

© The Author(s) 2025.Over 1 million cases of prostate cancer are reported every year, and it is the second most common cancer in men. Androgen deprivation therapy (ADT) is a hallmark treatment for prostate cancer but is associated with the development or exacerbation of cardiovascular disease. The most common cause of non-cancer death in patients with prostate cancer is cardiovascular disease. Thus, a better understanding of the prevalence of cardiovascular toxicity across all therapies, management of potential cardiovascular complications, and prevention of cardiovascular events is essential as treatments continue to evolve. In this article, the first in a 2-part series, we provide a review of the current landscape of ADT therapy and its association with cardiovascular disease, summarize recent clinical trial data evaluating cardiovascular outcomes, and provide insights on the management of cardiovascular risk factors and adverse events for clinicians managing this high-risk population of men undergoing potentially cardiotoxic treatment for prostate cancer.


Publication metadata

Author(s): Shah NP, Singh A, Higano T, Tilki D, Fleshner N, Nguyen P, Plummer C, Rivas JG, Zhang K, Rendon R, Morgans A, Cirne F, Leong D, Lenihan D, Lopes RD

Publication type: Letter

Publication status: Published

Journal: Cardio-Oncology

Year: 2025

Volume: 11

Issue: 1

Online publication date: 29/03/2025

Acceptance date: 07/02/2025

ISSN (electronic): 2057-3804

Publisher: BioMed Central Ltd

URL: https://doi.org/10.1186/s40959-025-00318-5

DOI: 10.1186/s40959-025-00318-5

Data Access Statement: No datasets were generated or analysed during the current study.


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