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Improved results in combination chemotherapy of head and neck cancer using a kinetically based approach: a randomised study with and without adriamycin

Lookup NU author(s): Professor Alan Calvert

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Abstract

One hundred and seventeen patients with advanced squamous cell carcinoma of the head and neck were randomised between two combination schedules, one with and the other without adramycin. Responses (more than 50% tumor regression) were 67% overall with 63% responding to the combination without adriamycin and 82% responding to the schedule containing it. The increase in response rate seen with the addition of adriamycin is not statistically significant. Prior radiotherapy reduced the likelihood of response to chemotherapy.

Publication metadata

Author(s): Price LA, Hill BT, Calvert AH, Dalley VM, Levene A, Busby ER, Schachter M, Shaw HJ

Publication type: Article

Publication status: Published

Journal: Oncology

Year: 1978

Volume: 35

Pages: 26-28

ISSN (print): 0890-9091

URL: http://dx.doi.org/10.1159/000225250

DOI: 10.1159/000225250

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