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Lookup NU author(s): Dr Louise Coats
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Author(s)Endothelial dysfunction is characterized by a vasoconstricted, pro-coagulative, and pro-inflammatory phenotype and is known to play a role in several chronic non-communicable diseases. Several biophysical and biochemical markers have been developed to assess endothelial function clinically. Its relevance in individuals born with single-ventricle congenital heart disease (SV-CHD) is increasingly recognized. Endothelial dysfunction has been observed in all stages of palliation in SV-CHD patients. Several mechanisms possibly contribute, including genetic factors, hypoxia, loss of pulsatility of blood flow, neurohormonal and sympathetic overactivation, and oxidative stress. Clinically, it possibly contributes to impaired pulmonary flow, exercise limitation, thromboembolisms, liver dysfunction, and adverse pregnancy outcomes. Based on this information, several therapeutic targets have been proposed such as early surgical and exercise interventions, pulmonary vasodilators, and other common pharmacological agents. However, much remains unknown and future studies must unravel the relationship of endothelial dysfunction with this complex patient group, ultimately improving their clinical care.
Author(s): Agarwal R, Coats LE, Zaidi AN
Publication type: Review
Publication status: Published
Journal: International Journal of Cardiology Congenital Heart Disease
Year: 2025
Volume: 20
Print publication date: 01/06/2025
Online publication date: 28/04/2025
Acceptance date: 26/04/2025
ISSN (electronic): 2666-6685
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.ijcchd.2025.100589
DOI: 10.1016/j.ijcchd.2025.100589
Data Access Statement: No data was generated for this review article.
