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Lookup NU author(s): Dr Jemma Cleminson, Dr Greg YoungORCiD, Dr David Campbell, Dr Fiona CampbellORCiD, Professor Andrew GenneryORCiD, Professor Janet Berrington, Professor Christopher StewartORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025.Impact: Children with short bowel syndrome depend on parenteral nutrition, which carries significant risks. Short bowel syndrome patients show reduced gut microbial diversity, increased inflammation-associated bacteria, and fewer beneficial bacteria. This is the first systematic review and meta-analysis examining the gut microbiome in children with short bowel syndrome. The review demonstrated significantly lower bacterial diversity and richness in children with short bowel syndrome, regardless of achievement of intestinal autonomy. Diversity and richness were greater in children who achieved intestinal autonomy than those on parenteral nutrition, though not statistically significant. Larger studies adjusting for confounding factors may identify future therapeutic strategies.
Author(s): Cleminson JS, Young GR, Campbell DI, Campbell F, Gennery AR, Berrington JE, Stewart CJ
Publication type: Article
Publication status: Published
Journal: Pediatric Research
Year: 2025
Pages: epub ahead of print
Online publication date: 07/05/2025
Acceptance date: 16/03/2025
Date deposited: 27/05/2025
ISSN (print): 0031-3998
ISSN (electronic): 1530-0447
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41390-025-04083-0
DOI: 10.1038/s41390-025-04083-0
Data Access Statement: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
PubMed id: 40335641
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