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Lookup NU author(s): Dr Corey ChanORCiD
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Aims: The prognostic role of systemic inflammatory biomarkers in patients with chondrosarcoma remains unclear, and evidence is lacking. The modified Glasgow Prognostic Score (mGPS) is an inflammation-based prognostic score consisting of preoperative CRP and albumin. This has been validated for a number of carcinomas and soft-tissue sarcoma, where its use is recommended. This national multicentre study aimed to investigate the prognostic significance of preoperative systemic inflammatory biomarkers, primarily the mGPS, in the prediction of survival in patients with a chondrosarcoma. Methods: Patients who had undergone an elective resection of a primary or secondary chondrosarcoma between January 2006 and December 2020 were identified from the prospectively maintained databases of seven collaborating UK bone sarcoma units. Laboratory and clinical data, as well as oncological outcomes, were collected from the patient records with a minimum of two years of follow-up. Data were analyzed using Kaplan-Meier survival and uni- and multivariate analysis. Results: A total of 549 patients were included in our study. We found that increased mGPS, tumour grade, size, age, local recurrence, metastasis, and inflammatory markers were significantly associated with reduced overall survival. mGPS was able to stratify the overall survival of patients in all grades of chondrosarcoma, especially when divided into mGPS score 0 versus mGPS 1 or 2. Conclusion: Our findings indicate that inflammatory markers and mGPS strongly correlate with the survival of patients with a chondrosarcoma. We recommend its use in their early assessment to better stratify prognosis, reinforce decision-making, and potentially improve outcomes.
Author(s): Ben Gal O, Doonan J, Lotfi N, McMahon S, Baker G, Cribb G, Chan CD, Siddiqi MA, Gupta S
Publication type: Article
Publication status: Published
Journal: Bone & Joint Journal
Year: 2025
Volume: 107-B
Issue: 6
Pages: 649-656
Print publication date: 01/06/2025
Acceptance date: 26/03/2025
ISSN (print): 2049-4394
ISSN (electronic): 2049-4408
Publisher: British Editorial Society of Bone & Joint Surgery
URL: https://doi.org/10.1302/0301-620X.107B6.BJJ-2024-0596.R2
DOI: 10.1302/0301-620X.107B6.BJJ-2024-0596.R2
PubMed id: 40449541
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